Manly and Parramatta close out Round 18 with an intriguing contest.
Gold Coast would have been dreading this contest with minor premiers in-waiting Melbourne but with the Storm resting most of their Origin stars, they will hope they can find a chink in the armour.
The last time these two teams met, London produced the shock of the season as they edged a golden point thriller against the league leaders and may be able to repeat that feat against a hugely under-strength Saints team.
Leeds failed to capitalise on the chance to give themselves some breathing space at the foot of the table as they were well beaten by Hull KR.
Castleford produced one of their better displays of the season with their win over Wakefield and will want to build on that against Warrington.
This is a huge game between two play-off hopefuls as they attempt to put winning runs together.
Canberra bounced back from their disappointing defeat against Parramatta as the Raiders were too good for St. George despite going down to 12-men in the second half.
Sydney Roosters are in a slump at the moment and their spot in the top 4 looks far from secure.
North Queensland have shown to be a dogged outfit this year and they overcame great adversity once again last week as they beat Sydney Roosters and keep themselves within play-off contention but face another tough test in South Sydney here.
Penrith and St. George have gone in very different directions over the last two months and their meeting here could highlight the gap between where they are currently at.
Hull KR will be hoping to make it back-to-back wins as they look to build on their superb win over Leeds last week.
New Zealand Warriors head to Wellington to host Cronulla in what is a pivotal game for both teams.
Wigan's winning streak came to an end against St. Helens but they can bounce straight back as they host Wakefield.
Brisbane are in last chance saloon when it comes to making the play-offs with their chances fading despite picking up a point last week.