Portland head to Seattle to face the Sounders with some solid away form behind them having lost just two of their last eight games on the road.
New York RB's winless run on the road continued as they went down to a third defeat in four away matches when facing Toronto last time out.
Vancouver Whitecaps have failed to win any of their last seven MLS games and have only won one of their last five on home turf.
Toronto have turned their form around and have now lost just one of their last five MLS matches whilst they also hold the same record on home turf.
Sporting KC have won their last two games in the MLS and now host a Dallas outfit that have failed to win any of their last six away games.
Minnesota United play like a different side when playing at home compared to away.
Philadelphia Union have only lost one of their last ten MLS matches on home soil and now host a Chicago Fire side that struggle on the road.
Columbus Crew snapped their five-game losing streak when they took a point from their trip to Chicago Fire but are still without a win from their last ten games.
Colorado Rapids have won four of their last five on home turf but face a tricky test against a New York City side that are strong away from home having lost just one of their last seven away games.
New England will head to Cincinnati full of confidence after improving their unbeaten run to nine matches with a 4-0 win against Vancouver Whitecaps.
Atlanta improved their unbeaten home record to eight matches with a thumping 5-0 win over Houston Dynamo.
The Los Angeles derby sees both teams come into the game in contrasting form with LA Galaxy only managing to win one of their last five home matches.
Portland Timbers improved their home record to just one defeat on home turf from their last 11 MLS matches when drawing with Colorado Rapids.